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SAS Journal of Medicine | Volume-1 | Issue-03
Comparison of Effect of Lidocaine and Dexmedetomidine for Prevention of Propofol Induced Pain: A Prospective, Randomized, Double Blind Controlled Study
Kiran Kumar S, Kishan Rao B
Published: Oct. 30, 2015 |
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78
DOI: 10.36347/sasjm.2015.v01i03.011
Pages: Page: 111-115
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Abstract
Propofol, an intravenous anesthetic widely used for general anaesthesia cause severe pain in most of people.
The aim of this study was to compare effect of lidocaine and dexmedetomidine for prevention of propofol induced pain.
The patients received normal saline (5 ml) in Group I, 0.5μg/kg of dexmedetomidine diluted in 5 ml normal saline in
Group II, and 0.5 mg/kg of lidocaine diluted in 5 ml normal saline in Group III through intravenous route. The study drug
was injected through the cannula over 5s and 25% of the induction dose of propofol (2 mg/kg) was administered over 10s
by a mechanical syringe and Pain was graded using the four point scale. In control group 10%, 12%,32%, and 46%
patients said no, mild, moderate, severe pain respectively while in dexmedetomine group 52%,44%, and 4% patients said
no, mild and moderate pain respectively. In the lidocaine group 64%,34% and 2% patients said no, mild and moderate
pain respectively. In both groups none of the patient complained severe pain. These drugs were effective in reducing the
propofol injection pain compared to control group, but lidocaine was better than dexmedetomidine.