DOI: 10.36347/sjams.2018.v06i05.069

Pages: 2234-2241

The incidence of prematurity has risen drastically over the last twenty-five years. Premature deliveries are the leading cause of neonatal morbidity and mortality in the United States. One of the primary setbacks to establishing full enteral feeds in preterm infants is feeding intolerance. Certain bioactive substances and live cells in milk appear to influence neonatal gut maturation and growth through their transfer of developmental information to the newborn. The aim of the present study was to evaluate the effect of enteral administration of insulin in preterm infants born less than 32 weeks gestational age and weighing less than 1500 grams to determine whether enteral insulin supplement to the basic preterm formula enhances feeding tolerance or not. Also, to detect weight gain in infants after receiving enteral insulin compared to those not receiving enteral insulin. 50 of the preterm infants fulfilling the fore-mentioned criteria received 1 U/kg regular human insulin every six hours and other 50 of the preterm infant fulfilling the mentioned criteria were fed preterm milk formula without receiving regular human insulin and criteria of feeding intolerance will be monitored the Predictive Analytics Software (PASW Statistics version 18)., we found that feeding intolerance attacks are less frequent with preterm babies who received enteral insulin. Feeding intolerance is frequently encountered in the neonatal intensive care unit and the use of enteral insulin is a promising therapy that enhance GI development and reduce feed intolerance in preterm infants.