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Scholars Journal of Applied Medical Sciences | Volume-8 | Issue-03
A Study of Hepatic Dysfunction with Severity of Dengue Fever
Dr. Riyaz Ahmed, Dr. Kavya ST, Dr. Amar Prakash Aravind
Published: March 21, 2020 | 57 37
Background: Dengue viruses belong to flavivirus, which include four serotypes 1,2,3 and 4. Dengue virus infection manifestations vary from asymptomatic to severe dengue with shock. An estimated 50 million dengue infections occur annually and approximately 2.5 billion people live in dengue endemic countries. Liver is affected in the form of derangements of liver function tests. Objectives: 1. to study the frequency and pattern of hepatic dysfunction in dengue fever 2. To find out the correlation of Hepatic dysfunction with severity of Dengue fever. Methods: An observational cross-sectional study done on patients admitted in hospitals attached to Bangalore Medical College and Research Institute, Bangalore, Karnataka, between June 2019-November 2019. Confirmed Dengue patients are included after meeting inclusion and exclusion criteria. Complete Blood count, liver function tests are estimated at the time of admission. Results: Out of 100 patients, 27 developed Dengue fever with warning signs and 10 patients developed severe Dengue. Multivariate analysis showed that low albumin of <3.5 gm/dl was associated with severe dengue, which was statistically significant (p value 0.028). Conclusions: Early changes in liver enzymes and serum albumin may be detected in patients with dengue fever. Low serum albumin levels if present may be a marker of the critical phase of the disease and an early indicator of plasma leakage due to altered vascular permeability and a useful predictor of severity of dengue fever.