DOI: 10.36347/sjams.2018.v06i06.040

Pages: 2515-2518

Vitamin D, inspite of having role in maintaining the good functioning of bone metabolism, has anti-proliferative effect in cellular differentiation, immunomodulation and inhibition of the Renin - Angiotensin System (RAS). The aim was to assess the levels of serum 25-hydroxy vitamin D in patients with Diabetic nephropathy and to find the association between 25(OH)D levels and microalbuminuria in patients with Diabetic nephropathy. This case control study conducted after Ethical committee clearance comprised 50 Type 2 Diabetic nephropathy subjects & 20 age matched healthy individuals. ELISA-for serum 25- hydroxy vitamin D, GOD- POD for fasting glucose, Creatinine by Modified Jaffe’s method, Arsenazo III method for calcium, Ammonium molybdate method for phosphorus, Creatinine by Modified Jaffe’s method were studied. Urine Microalbumin was measured by Immunoturbidimetry method and Albumin Creatinine ratio was estimated. The mean 25 Hydroxy vitamin D concentration in patients with Diabetic nephropathy was 5.089±2.33ng/ml and in healthy individuals was 15.8805±3.91ng/mL, with highly significant p value (p= 0.0001). A negative linear correlation was seen between 25 hydroxy vitamin D levels and microalbumin (r = -0.703). Serum 25 hydroxy vitamin D was decreased in Diabetic nephropathy (Vitamin D deficiency), reduced in healthy individuals (Vitamin D insufficiency). Cautious supplementation with vitamin D may improve glycemic control and microalbuminuria in Type 2 DM.