DOI: 10.36347/sjams.2018.v06i07.015

Pages: 2686-2690

To study effect of Group B Streptococcus (GBS) infection on perinatal morbidity and mortality. The study included 986 pregnant females at 35-37 wks of gestational age attending the antenatal outpatient department at tertiary care hospital in northeastern India. All participants were screened by conventional method of two rectovaginal swabs for GBS colonization in Blood Agar media and secondly with serum for antigen detection by rapid latex test for use in qualitative detection of antigen from GBS by Wellcogen Strep B kit. Data of neonates born to GBS positive mothers were divided into Group A (GBS present) and Group B (GBS absent). Patients of Group A were alternatively divided into control Group (C) and Test Group (T). Only the Test Group [T] were given intrapartum antibiotics [IAP] whenever they went into labor. Antibiotics policy followed was as per CDC guidelines; Inj ampicillin 02gm I.V. stat followed by 01gm I.V. q 6 hours till delivery of the patient. Records of the clinical rupture of the membranes, its duration and any clinical signs of chorioamnionitis were maintained. Specific clinical signs that indicate high risk for early onset neonatal sepsis (EONS) by GBS such as fever >100.4°F, foul smelling liquor or fetal tachycardia were documented. All the neonates born to GBS positive mother with symptoms of EONS were recorded. A total of 986 antenatal women were screened for GBS carrier state between 35-37 weeks of gestation and were followed till delivery.