DOI: 10.21276/sasjm.2019.5.3.3

Pages: 51-58

This paper draws from the findings of a study conducted to establish the effect of Mondia whitei on the production of testosterone levels, Luteinizing Hormone (LH), and follicle stimulating hormone (FSH) in male albino rats. The target population comprised 32 albino male rats weighing between 200mg-300mg bought from University of Nairobi’s Chiromo Campus and housed at University of Eldoret’s animal house. ‘Mondia whitei’ was obtained from Kakamega town market and ground into powder using a laboratory mill. The rats were grouped into 4 categories, each of which consisted of 8 rats with Group I as the control and Groups II, III, and IV as test groups. The Mondia whitei extract was administered orally and blood sample collected through cardiac puncture after anaesthetizing the rats. Thereafter, the animals were sacrificed and their testes, epididymis, seminal vesicles and ventral prostrate dissected. Serum hormones was determined using ELECSYS (Cobas, USA). By use of SPSS Version 21.0, the analyzed data produced results showing insignificant differences (p>0.05) in serum concentrations after 10, 15 and 30 days in rats treated with M. whitei extract and negative control rats. After 10 days of treatment, highest serum testosterone of 6.03ng/ml was recorded in M. whitei treated rats with 100 mg/kg of the extract. Serum testosterone levels after 30 days of treatment were highest in negative control (4.67 ng/ml); nevertheless, this was insignificantly from those of rats treated with 200mg/kg (1.68ng/ml), 400mg/kg (2.64 ng/ml) and 100mg/kg (0.97ng/ml) of the extract.