DOI: 10.36347/sjams.2018.v06i07.052

Pages: 2902-2906

The aim of the study was to evaluate Event Related Potentials (ERPs) in patients with Vitamin B12 deficiency without neuropsychiatric symptoms and effect of Vitamin B12 supplementation on ERPs. The patients were divided into 3 groups according to their Serum Vitamin B12 levels. The serum levels of Vitamin B12 in the groups were- Group 1 - < 211pgm/ml (deficient), Group 2 - 211-350 pgm/ml (insufficient) and Group 3 - > 350pgm/ml (sufficient). Standardized Mini Mental State Examination (SMMSE) was done in all subjects at the time of entry point. ERPs study and SMMSE were repeated in subjects of group 1 after 3 months of Vitamin B12 supplementation. Latency of N200 and P300 of group 1 showed statistically significant difference when compared to group 2 and 3 before treatment (p<0.05) and the difference disappeared after 3 months of Vitamin B12 supplementation. The study concludes that ERP parameters are deranged prior to clinical manifestation of neuropsychiatric features in Vitamin B12 deficiency and can be used to assess efficacy of Vitamin B12 supplementation.