DOI: 10.36347/sjams.2018.v06i08.021

Pages: 3049-3054

Laparoscopic surgeries because of their benefits like small incision and pain due to it, early mobility, less infection rate, less postoperative analgesics usage etc. are preferred over open surgical procedures. But laparoscopic procedures also causes complications because of pneumoperitoneum created during surgeries by insufflattion of gases and its duration leads to blood pressure and heart rate changes. Various drugs of different groups are used to reduce the effect of pneumoperitoneum. Dexmedetomidine is a selective α- 2 agonists used for the same purpose with its various other benifits too. This randomized control study was conducted on 60 patients of ASA grade 1 and 2 after taking ethics committee approval. Group D (n=30) dexmedetomidine is infused during the surgery and in group C (n=30) normal saline is infused during the surgery. Diastolic and systolic blood pressure, mean arterial blood pressure and heart rate were measured throughout the procedure till 30 minutes after the procedure. Sedation score was also measured after the surgery. Effect of intubation and laryngoscopy induced stress response, creation of pneumoperitoneum, reversal of pneumoperitoneum and extubation was seen over heart rate, SBP, DBP and MAP in both the groups but was significantly less in the dexmedetomidine group(D) compared to the control(C) group showing better stability of the hemodynamic vitals in the patients given dexmedetomidine intraoperatively (P<0.05). Dexmedetomidine suppresses pneumoperitoneum induced hemodynamic instabilities in patients undergoing laparoscopic cholecystectomy under general anaesthesia.