DOI: 10.36347/sjams.2018.v06i08.022

Pages: 3055-3060

Laparoscopic surgeries are gaining importance nowadays because of their benefits and less complication rate when compared with open surgical procedures. But laparoscopic procedures are not free from complications too. Pneumoperitoneum created during laparoscopic procedure leads to hemodynamic instability. So many pharmacological agents are used to subside effect of pneumoperitoneum. Clonidine is one such agent which is an α- 2 agonist. This randomized control study was conducted on 60 patients of ASA grade 1 and 2 after taking ethics committee approval. Group CL (n=30) clonidine is infused during the surgery and in group C (n=30) normal saline is infused. Diastolic and systolic blood pressure, mean arterial blood pressure and heart rate were measured throughout the procedure till 30 minutes after the procedure. Sedation score was also measured after the surgery. Effect of intubation and laryngoscopy induced stress response, creation of pneumoperitoneum, reversal of pneumoperitoneum and extubation was seen over heart rate, SBP, DBP and MAP in both the groups but was significantly less in the clonidine(CL) group compared to the control(C) group showing better stability of the hemodynamic vitals in the patients given cloidine intraoperatively (P<0.05). Clonidine suppresses pneumoperitoneum induced hemodynamic instabilities in patients undergoing laparoscopic cholecystectomy under general anaesthesia.