DOI: 10.36347/sjams.2018.v06i08.046

Pages: 3169-3175

Type 2 diabetes mellitus is a hereditary disease, which has a close correlation with development of coronary artery disease. It has been shown that the HDL-associated enzyme, paraoxonase (PON1), is responsible for prevention of the oxidation of LDL, thereby protecting against complications like coronary artery disease and myocardial infarction in patients of diabetes mellitus. So, PON1 functions as an anti-oxidant. In this study, the paraoxonase (PON1) activity was correlated with the levels of HDL in serum of the patients of type II diabetes mellitus. There were 100 patients of type II diabetes mellitus, ranging from 40 to 80 years of age. A significant positive correlation was found between serum PON1 activity and HDL cholesterol levels. It appears that this association contributes to the protection conferred by HDL, against low density lipoproteins (LDL) peroxidation and subsequent development of coronary artery disease.