DOI: 10.36347/sjams.2020.v08i04.009

Pages: 1098-1101

Background: Despite being extremely common medical problem in India, the pathogenic mechanism of snake-bite induced acute kidney injury (AKI) remains elusive. Analysis of the risk factors for snake-bite induced AKI may be helpful in AKI prevention and early treatment. Methods: The study included 201 snake-bite patients who were hospitalized to our hospital during period of January 2019 to March 2020. The patients were divided into AKI and non-AKI groups. The Chi-square test, Student’s t-test were used for statistical analysis. Results: The mean age of patients was 40.5±9.5 years. Of the 201 patients 40.8% cases, (n=82) suffered from AKI. While, 33.3% (n=67) case suffered from severe AKI and needed renal replacement therapy. There were statistically significant differences between the AKI and non-AKI groups with respect to older age, female gender, time interval from snake bite to antivenom therapy, creatine kinase, Lactate Dehydrogenase (LDH), hemoglobin level, and presence of diabetes. Occurrence of AKI was very significantly associated with mortality risk (P value 0.0001). Conclusion: Occurrence of AKI was linked to advanced age, female sex, markers of hemolysis and muscle injury, delay in anti-snake venom therapy, and diabetes.