DOI: 10.36347/sjams.2018.v06i09.010

Pages: 3276-3285

Postoperative Surgical Stress, nausea and vomiting (PONV) continue to be highly undesirable outcomes of anesthesia and surgery. Therefore, multimodal approaches have been suggested in order to decrease PONV and surgical stress. The aim of this study was to evaluate stress markers (TLC & CRP) and antiemetic effect of a single dose injection of dexamethasone (8mg i.v.) on reducing postoperative surgical stress and PONV in laparoscopic cholecystectomy. In this prospective study, 60 patients aged 20-69 years, selected for laparoscopic cholecystectomy, were classified into study and control groups 30 patients in each group. The study group underwent general anesthesia with intravenous injection of dexamethasone. The Control group received general anesthesia and no intravenous injection of dexamethasone. TLC, CRP, Total dose of consumed analgesics and Ondensetron during first 24 hours were evaluated in both groups. Stress Markers (TLC & CRP) in study group were significantly less than control group after 6 and 24 hours of surgery. PONV and antiemetic requirement in study group was significantly less than control group after surgery. No significant difference existed between two groups regarding Hospital stay. Single dose of 8 mg of i.v. dexamethasone preoperatively is safe and effective and may be considered to minimize surgical stress response, PONV and antiemetic use.