DOI: 10.36347/sjams.2020.v08i04.011

Pages: 1108-1111

Introduction: Role of matching of HLA- antigen in the outcome of Kidney transplantation is a well-established fact. But properly matched donor selection is a difficult job. In order to observe the role of HLA-antigen matching in renal transplantation, this study was done in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Materials and methods: One hundred live related Kidney transplant cases were included in this study. All cases were divided into two groups, Group 1 (n=74) having much better HLA matched than Group 2(n=26) (p<0.001). The cases were ovserved retrospectively for one year from the data of transplantation. Results: After one year, level of serum creatinine was significantly higher in Group 2 in comparison to Group 1 (147.29 ± 33 µmol/lit vs 273.07±50 µmol/lit, p < 0.05). Rate of Acute rejection was higher in group 2, than Group 1(22.97% vs 57.70%, p < 0.001). Graft survival was significantly better in Group 1 than in Group 2 (90.54% bs 65.88%, p < 0.05). Conclusion: Kidney transplantation should be done with good HLA matching between donor and recipient. As poor HLA matching is found to have poor outcome and better HLA matching in live kidney transplantation is found to have better graft outcome.