DOI: 10.36347/sjams.2018.v06i09.027

Pages: 3367-3373

The increased use of regional anaesthesia in recent years has led to an increased need for sedation during surgery in awake patients. Our study aim to compare the hemodynamic, duration of anaesthesia and perioperative adverse events with intravenous Dexmedetomidine and intravenous Propofol when used as an adjuvant to regional anaesthesia in joint replacement surgeries.Prospective pilot study enrolled 100 patient posted for unilateral knee replacement surgery, divided in two groups– Dexmedetomidine – group D and Propofol – group P. Patient in Group D receive intravenously Dexmedetomidine which is diluted with normal saline in a concentration of 4μg/ml and Group P receive intravenously Propofol in a concentration of 10mg/ml, firstly a loading dose and then a maintenance infusion titrated to achieve OAA/S score of 3, as per study protocol. Analysis of significance of study parameters on continuous scale by student T test,(intergroup analysis) in means between two groups and the difference in proportion by using chi square test.