DOI: 10.36347/sjams.2018.v06i09.074

Pages: 3608-3611

Alcohol related liver disease is a major cause of morbidity and mortality worldwide. Chronic alcohol consumption leads to hepatocellular injury, fat accumulation and liver inflammation. Progression of ALD is well characterized and is actually a spectrum of liver diseases, which ranges initially from simple steatosis, to inflammation and necrosis (steatohepatitis), to fibrosis and cirrhosis. The study was designed to determine effects of stress marker enzymes and other biochemical parameters in alcoholic liver disease patients with reference to the normal healthy individuals. 175 alcoholic liver disease patients were enrolled for the study & were compared to 150 normal healthy individuals of the same age. Those fulfilling inclusion & exclusion criteria were enrolled for the study & the blood samples were analysed for lipid profile, LFT, plasma MDA and SOD. Significant higher concentrations of MDA (P<0.001), GGT (P<0.001) and lower concentration of SOD (P<0.001) & Protein (p<0.001) was demonstrated in patients with alcoholic liver disease when compared with normal healthy individuals controls. The risk of alcoholic liver disease (ALD) increases in a dose & time dependent manner with consumption of alcohol.