DOI: 10.36347/sjams.2018.v06i09.075

Pages: 3612-3616

Oxidative stress and lipid accumulation are major contributors in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The purpose of this study was to find the relation between oxidative stress parameters and histopathological findings in NAFLD patients. The study was designed to determine effects of stress marker enzymes and other biochemical parameters in non-alcoholic fatty liver disease patients with reference to the normal healthy individuals. 175 non-alcoholic fatty liver disease patients were enrolled for the study & were compared with 150 normal healthy individuals of the same age. Those fulfilling inclusion & exclusion criteria were enrolled for the study & the blood samples were analysed for lipid profile, LFT, plasma MDA and SOD. Significant higher concentrations of MDA (P<0.001), GGT (P<0.001) and lower concentration of SOD (P<0.001) & Protein (p<0.001) was demonstrated in patients with non-alcoholic fatt liver disease when compared with normal healthy individuals controls. This study shows that NAFLD correlates with enhanced oxidative stress. Histopathological disease severity significantly correlated with oxidative stress parameters.