DOI: 10.36347/sjams.2018.v06i09.076

Pages: 3617-3622

Diabetes is closely related to the development of coronary artery disease (CAD) and myocardial infarction (MI). The oxidative modification of low-density lipoprotein (LDL) in the artery wall is currently believed to be central to the pathogenesis of atherosclerosis. Oxidized LDL has also been shown to be cytotoxic to capillary endothelial cells. The inverse relationship between serum PON activity and the risk for atherosclerotic diseases suggests that PON hydrolytic activity on oxidized LDL may be related to its antiatherogenicity. Serum PON activity is decreased in subjects who have had a myocardial infarction and in subjects with type I and type II diabetes. In this study human serum paraoxonase activity in patients with type II diabetes mellitus were compared to that of control subjects. 100 patients and 30 controls were taken. The result of this study revealed that the PON activity of the patients of type 2 diabetes mellitus was lower than that of the controls. As PON is known to be an antioxidant, the decreased PON activity could be responsible for increased levels of ox-LDL in these patients with consequent development of diseases like myocardial infarction and hypertension.