DOI: 10.36347/sjams.2018.v06i09.079

Pages: 3633-3637

Coronary artery disease is major health problem. Various markers are being studied to diagnose significant coronary artery disease. We conducted this prospective observational study to find any association of mean platelet volume (MPV), SGOT and CPKMB with significant coronary artery disease.A total of 110 patients with acute coronary syndromes were included in the study. All patients underwent coronary angiogram and percutaneous intervention whenever indicated. Association of MPV, SGOT and CPK-MB was tested with presence of significant coronary disease. MPV was significantly higher in hypertensive & those who required coronary intervention (p value 0.014 &<0.001 respectively). Two or three vessel-involved-subjects were having significantly higher MPV than those with no or single major vessel involvement. (two vessel v/s normal or single vessel, MPV 10.66 +/-1.52 p value 0.03, three vessel v/s normal or single vessel, MPV 11.55+/-1.51 p value <0.001). Patients with LAD as the involved vessel had higher MPV values 10.55 +/-1.64, than those without LAD involvement 9.58+/-1.45 (p-value 0.03).Significant but weak negative correlation was observed between MPV & Left ventricular ejection fraction (LVEF) of heart (Pearson correlation -0.192, p 0.04). CPKMB and SGOT are sensitive for acute myocardial injury but not studied in association with significant coronary artery diseases. We observed that MPV was higher in patients with significant coronary disease, ≥2vessel disease and those with LAD involvement. MPV can be considered as a marker of significant coronary artery disease.