DOI: 10.36347/sjams.2018.v06i10.005

Pages: 3688-3693

The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are pretreatment inflammation based prognostic biomarkers used to predict oncologic outcomes in urological and gastrointestinal malignancies. Limited literatures are available in determining their value in prediction of invasiveness of bladder cancer in pretreatment scenario. The current study is conducted to evaluate the predictive value of pre-treatment inflammation based prognostic biomarkers to determine the invasiveness of primary bladder cancer in patients undergoing transurethral resection of bladder tumour (TURBT) surgery. Total 120 primary bladder tumour patients, who underwent TURBT from April, 2016 to March, 2018 in department of Urology, Calcutta National Medical College, Kolkata, were prospectively studied for detection of muscle invasion. The Case Record Proforma (CRP) of Bladder Tumour Registry of our institution was used to document patient demographics, tumour characteristics and prognostic scores of inflammatory biomarkers. Among 120 patients, 76.7% of patients had Nonmuscle invasive bladder cancer and rest had muscle invasive variety. The cut-off values for NLR, LMR and PLR were 3.18, 3.67 and 185.67, respectively. Multivariate logistic regression analysis showed that high grade, larger sized tumor, high NLR and PLR values were independent predictors of muscle invasion. NLR and PLR were identified to be simple, cost-effective and easily measured prognostic biomarker for muscle invasion. These markers will also assist in the preoperative planning and counselling for further treatment and follow-up.