DOI: 10.36347/sjams.2018.v06i10.022

Pages: 3779-3783

Platelet-rich plasma (PRP) is considered as an innovative and promising tool to stimulate repair of the damaged cartilage. PRP is a concentration of several protein growth factors which stimulate cell proliferation, migration, differentiation, and matrix synthesis and can affect chondrocyte metabolism and improve cartilage healing. A total of 42 patients with symptomatic Kellgren-Lawrence grade 1 and 2 osteoarthritis (OA) of Knee Joint were enrolled in this study in 2015. Patients were treated with an autologous single PRP intra articular injection (IAI). Results were assessed using Visual analog scale (VAS) and Knee injury and Osteoarthritis Outcome Score (KOOS). Both variables were assessed pre injection and at 3 weeks, 1 month, 3 months, and 6 months after treatment. There was stastically significant improvement in both variables at 6 months follow up. A single PRP IAI is effective for relieving pain and improving activities of daily living in early stage knee OA.