DOI: 10.36347/sjams.2018.v06i10.036

Pages: 3863-3872

To study the frequency and outcome of AKI in children using paediatric rifle criteria. Prospective observational study. All children admitted in PICU over six months' period, from August 2016 to January 2017, in age group of >1 month to 13 years are taken as study group according to the inclusion criteria. All the children of the study group were assigned baseline creatinine clearance value of 100ml/min/1.73m2. Creatinine clearance of every child is calculated by using Revised Schwartz formula. For children with deranged creatinine clearance at admission in to PICU or during stay in hospital, pRIFLE class is established. Maximum pRIFLE strata attained by children is documented, outcomes were noted and studied. Primary outcome (mortality) and secondary outcome (morbidity) is measured by Length of stay (LOS) in PICU. A total of 26 children of entire study population are dead (26/200, 13%).12 children with AKI are died (12/58, 20.68%). Death rate in children with AKI is 2.09 times more than Non AKI group. Deaths among AKI were analyzed, Of the Injury category 4 children died (4/18, 22.22%).6 children from failure category were dead (6/14, 42.85%). LOS in PICU in children with AKI group is high with a mean LOS of 7.89+/-3.49(95% CI of 0.91< 2-18>) compared to LOS of non AKI patients 4.34+/-1.86(95% CI of 0.30<1-12>).When LOS in hospital is evaluated AKI children had mean of 12.43+/-5.29(95% CI 1.39 <2-30>) compared to non AKI children 8.17+/-3.29(95% CI 0.54<1-30>), which is significant (P<0.05).. SCr and UOP seem to be late markers of renal injury, use of classification systems and other serum biomarkers are required to detect AKI earlier to prevent AKI in children prior to a rise in SCr concentration. 2. AKI had increased LOS in PICU, and increased mortality.