DOI: 10.36347/sjams.2018.v06i10.046

Pages: 3918-3920

Major orthopedic surgeries are commonly associated with marked blood loss, which is associated with post operative mortality and morbidity. The causes of bleeding are multifactorial, increased fibrinolytic activity being one of them. Antifibrinolytic activity of Tranexamic acid may reduce peri-operative blood loss. To study the effect of inj. Tranexamic acid in reducing post operative blood loss. The present randomized control study was conducted on 41 patients with fracture neck femur who undergone bipolar hemiarthroplasty at tertiary care teaching hospital of medical college. All the participants were randomly divided in to test and control group. Test group (n=21) patients received injection Tranexamic acid and control group (n=20) received placebo. The average amount of blood loss in test group and placebo group was 400-450 ml and 700 to 1000 ml respectively. Blood loss was found to be 60% less in test group as compared to placebo group. The present study conclude that, injection Tranexamic acid may be use as anti-fibrinolytic to control blood loss during pre and post hemiarthoplasty of trance cervical fracture neck femur.