DOI: 10.36347/sjams.2018.v06i10.080

Pages: 4068-4071

India is becoming Diabetic capital of the world with a parallel increase in long term complications associated with Diabetes. This study was done to evaluate Cystatin C as a marker for detecting early renal dysfunction in Diabetic Nephropathy. Serum Cystatin C and Urine Albumin levels were measured in 100 type 2 Diabetics alongwith other parameters like FBS, HbA1c, Serum Urea and Creatinine, blood pressure and lipid profile. e GFR was calculated using CKD-EPI equations.Mean Cystatin C concentrations showed stepwise statistically significant increases as eGFR reduces and also increases with increasing level of albuminuria(p<0.001). Among normoalbuminuric patients(n =46), 17.4 % patients were having increased Serum Cystatin C as compared to 4.3% patients having increased Serum Creatinine( p<0.001).In ROC analysis, area under curve of Serum Cystatin C is 0.758 (p<0.001) which signify that Serum Cystatin can be a fair predictor of Nephropathy. Glycemic control, blood pressure and dyslipidemia were directly related with albuminuria and eGFR. This study supports the use of Cystatin C for detecting early renal dysfunction as compared to conventional markers.