DOI: 10.36347/sasjm.2023.v09i10.003

Pages: 1056-1060

Background: Type 2 diabetes mellitus (T2DM) and prostate cancer (Pca) are two different disease entities that occur frequently in the elderly populations. Researchers have identified some mechanisms that could link T2DM to the development, progression and prognosis of Pca. Although controversies surround this concept, T2DM has been reported to confer protection to the development of low grade Pca and to a lesser extent high grade Pca. Materials and Methods: One hundred and thirty-six (136) men with Pca were evaluated in this study. Information from their case-notes were retrospectively retrieved during their clinic visits including bio-data, history, physical examination findings, laboratory and radiological investigation results and reports of prostate biopsy. Patients were grouped as diabetic and non-diabetic based on the history and laboratory records. Age and prostate specific antigen (PSA) levels were also categorized. Collated data were analyzed using the Statistical Package for Social Sciences (SPSS) version 20.0 software. Results: One hundred and thirty six (136) men with a mean age of 69.10±8.40 years ranging from 48 to 91 years and diagnosed with Pca were evaluated. Diabetic men were older and had higher mean serum PSA and Gleason score (GS) than non-diabetic men (Table3i – iii). Conclusion: Diabetic men in this study had higher values of variables portraying more aggressive Pca than non-diabetic men. Therefore, in evaluating this group of patients presenting with symptoms suspicious of Pca, concerns of probably dealing with highly aggressive tumours should be held strong.