DOI: 10.36347/sasjm.2023.v09i10.006

Pages: 1071-1072

Chronic renal disease (CRD) gradually leads to metabolic alterations and numerous nutritional and hormonal dysfunctions. In the long term, these alterations are at the origin of complications such as disturbances of phosphocalcium metabolism and hypothalamic-hypophyseal abnormalities which are at the origin of complex disturbances of thyroid secretions, adrenal prolactinin...We carried out a retrospective study in 24 patients followed at the Avicenne military hospital in Marrekech, these are patients with chronic renal insufficiency in whom a hydro-electrolyte and hormonal assessment was carried out. Our objective was to highlight the endocrine disturbances associated with chronic renal disease. The average age of our patients was 57 years +/- 22 years. Men represented 75% of the study population, compared to 25% of women with a sex ratio of 0.3). Renal disease was stage 3 in 16% of cases, stage 4 in 25% of cases, and stage 5 in 59% of cases. Hypocalcemia was found in 71% of cases, hyperphosphoremia in 33% of cases and elevated alkaline phosphatase in 12.5% of cases. Hyperparathormonaemia was observed in 75% of cases, with an average PTH level 9 times normal. In 89% of the cases the patients were in vitamin D insufficiency and in 22% of the cases the patients were in deficiency. A disturbance of the thyroid balance was noted in 13% of cases. Hyperprolactinaemia was observed in 8% of men and 4% of women. Regarding cortisol, the elevation in a single case was moderate representing 4% of cases.