DOI: 10.36347/sjmcr.2023.v11i10.033

Pages: 1851-1853

Holoprosencephaly is a rare and a complex congenital brain malformation resulting from defective cleavage of the prosencephalon that occurs at 4 - 8th week of gestation and is usually associated with multiple cranio facial anomalies. It is the most common forebrain developmental anomaly in humans and a worldwide distribution. The etiology of HPE is very heterogeneous it has an extremely reserved fetal prognosis, particularly for the alobar form. Here, we report a case of holoprosencephaly alobar of a 24-day old boy, with microcephaly, flat nose, a single nostril, midline cleft lip palate and choanal atresia.