DOI: 10.36347/sjams.2020.v08i05.013

Pages: 1235-1238

Background: Mifepristone when is combined with misoprostol for induction of labour at term, it has shown to decrease the dose, thus the side effects of misoprostol. Objective: The aim of our study was to compare the efficacy of mifepristone and misoprostol regimen with misoprostol alone for induction of labour at term. Material and method: A total of 100 pregnant women with singleton pregnancy, cephalic presentation, gestational age of 37-41 weeks, Bishop score ≤6 were enrolled at a tertiary care center in India and randomized into two groups alternately. Group I received 200 mg of mifepristone orally on day one. Repeat Bishop score was done after 24 hours and if ≤6 then 25 µg of misoprostol was administered vaginally repeated at four hourly intervals upto maximum of six doses. Group II received 25 µg of misoprostol per vaginally at four hourly intervals upto maximum of six doses. In both the groups Bishop score was <6 after six doses, then induction attempt was considered as failure and was taken for caesarean section. Results: There was significant difference in the total no. of doses required for vaginal delivery (1.42+1.35 vs 2.66+1.03 p<0.001), misoprostol induction to favourable bishop score interval (8.07±0.85 and 8.41±0.58 hours p<0.01), misoprostol induction to delivery interval (8.46±4.60 vs 12.13±4.23 hours, p<0.001) between two groups. Conclusion: Administration of mifepristone before misoprostol appears to be safe and better than misoprostol alone as there is significant improvement in Bishop score after 24 hours of mifepristone, reduction in number of doses of misoprostol required, shorter misoprostol induction to delivery interval and good number of vaginal deliveries within 24 hours without any requirement of misoprostol.