DOI: 10.36347/sjams.2023.v11i11.003

Pages: 1877-1880

Introduction: Autoimmune hepatitis (AIH) is a chronic inflammatory disease of the liver linked to an immunological response directed against hepatocytes. Their etiopathogenic mechanism involves several factors: viruses, bacteria and drugs as agents triggering autoimmunization [1, 2]. It is relatively rare and of unknown etiology. There are two types (I, II) associated with the presence of certain auto-antibodies. These diseases are characterized by an anatomo- clinical and immunobiological polymorphism, which can lead to diagnostic and therapeutic difficulties, and therefore medical management [3]. The presence of auto-antibodies (auto-Ab), associated with different categories of AIH, would be of great help at the diagnostic and sometimes prognostic level, justifying their interest in clinical practice. Materials and Methods: The objective of our work is to analyze the epidemiological, clinical, para-clinical and immunological profile of this affection through a retrospective study including the cases of AIH followed at the Department of Internal Medicine within the Military Hospital Moulay Ismaïl of Meknes (HMMI) over a period of 05 years from January 2013 to December 2017. Results: The age of our patients varies between 30 and 48 years old with an average of 39 years old. There is a clear female predominance (4 women and one Man). The clinical signs are dominated by jaundice, found in 4 patients, i.e. 80% of cases, it was accompanied by: pruritus in 2 patients; asthenia, anorexia and arthralgia in one patient; of ascites in a patient. Biologically, hepatic cytolysis was found in all our patients. A marked biological cholestasis was observed in 2 patients, hypergammaglobulinemia was found in all cases with predominance on IgG. Immunologically, AIH was type 1 (ANA, SMA) in 80% of cases and type 2 (anti-LKM1) in 20% of cases. On the histological panel, a morphological aspect of active hepatitis in favor of AIH is found in 3 cases, an alteration of the bile ..........