DOI: 10.36347/sasjs.2023.v09i11.011

Pages: 924-931

Introduction: Medication-related osteonecrosis of the jaw (MRONJ) is a challenging condition with no established gold standard treatment. This article presents a case series that explores a minimally invasive surgical protocol combined with various adjuvant treatments to manage MRONJ in oncologic patients. Patient and Methods: Seven patients diagnosed with MRONJ, with mandibular involvement at stages 2 and 3 were included in the case series. The treatment protocol consisted of pre-operative steps, including oral cavity sanitation, hygiene motivation, and pre-operative medical treatment. Using operative techniques, the surgical protocol involved fluorescence-guided bone debridement, curettage, and bone smoothing. Adjuvant treatments such as platelet-rich fibrin, buccal fat pad grafts, Pentoxifylline and tocopherol combination, and low-level laser therapy were used. Follow-up assessments were conducted at regular intervals, and the outcomes were evaluated. Result: Improved cicatrization and symptom relief in most cases, with complete healing achieved in all patients. Conclusion: The study highlights the outcome of the use of adjuvant therapies in the management of MRONJ, however, further research is needed in order to acknowledge the potential of adjuvant therapies for MRONJ treatment and establish a standardized protocol.