DOI: 10.36347/sajb.2018.v06i11.001

Pages: 676-681

The aim of this study was to evaluate the antihypertensive effect of Tanopati in hypertensive rabbits. Tanopati is a traditional recipe made from the parts of five plants, namely Ageratum conyzoides, Newbouldia laevis Phyllanthus muellerianus, Cassia occidentalis and Aloe vera. The extract of Tanopati was obtained after drying of its decoction at 40 °C for 5 days. The experimental hypertension was induced by intramuscular injection with 0.75 mL of adrenalin at a dose of 1 mg/ml in normotensive rabbits. Once installed hypertension, these rabbits of test group received by gavage 1 ml of Tanopati at a dose of 11 mg/kg bw and those of control group 1 mL of furosemide® at dose of 20 mg/kg bw by gavage. Results showed that Tanopati at dose 11 mg/kg bw increased significantly urinary excretion of sodium compared to the control (p <0.001). Tanopati while reducing the plasma level of creatinine increased significantly (p <0.001) its urinary rate as well as its clearance. So, this elimination of sodium would be the consequence of an increase in the glomerular filtration rate, like diuretics of loop such as furosemide®. The antihypertensive effect of Tanopati would thus be exerted by a natriuretic effect, ie the urinary elimination of sodium.