DOI: 10.36347/sajb.2018.v06i05.002

Pages: 399-403

In the present study was carried out to evaluate the anticancer potential of Drosera peltata J.E.Sm against Ehrlich's Ascites Carcinoma (EAC) induced tumor in mice. The ethanol and aqueous extract of Drosera peltata J.E.Sm. was given orally to mice at the dose of 250, 500 mg/kg body weight for 14 days to EAC bearing mice (4 Groups n=10) and 20mg/kg of 5-Fluorouracil (1 group as standard). Phytoconstituents of both extracts were analyzed through HPTLC methods using plumbagin and quercetin as a standard marker. Treatment caused significant reduction in body weight, packed cell volume (PCV) and viable tumor cell count when compared to the mice of the EAC control group. Restoration of hematological parameters towards normal was also observed. The dose at 250,500mg/kg of ethanol extracts and 500mg/kg of aqueous extract showed significant (p<0.001) result when compared with 250mg/kg of aqueous extract dose. HPTLC study confirmed that presence of plumbagin and quercetin in ethanol and aqueous extract. The results concluded that the ethanol and aqueous extracts of Drosera peltata, exhibited significant anticancer activity in EAC bearing mice which might be the presence of phytoconstituent plumbagin and quercetin.