DOI: 10.36347/sajb.2018.v06i10.005

Pages: 660-663

Aetiology of urinary stone disease is a function of multiple factors. Besides physicochemical aspects of crystal aggregation and stone formation, studies on the role of oxidative stress in urolithiasis are also getting attention in recent years. The objective of the present study is to trace the status of antioxidant vitamins viz., vitamin-A and vitamin-E, in urinary stone disease. Twenty five urolithiasis patients, 20 male and 5 females in the age group of 20 to 55 years, were selected for study. Twenty normal healthy persons, 14 male and 6 females in the age group of 20 to 55 years were also selected for study as controls. Serum retinol (vitamin-A), and serum α-tocopherol (vitamin-E) levels of subjects (patients) and controls were estimated. Results revealed that the levels of vitamin-A and vitamin-E in the stone patients were significantly lower (p < 0.03 for vitamin-A & p < 0.006 for vitamin-E) than that of the normal healthy persons. As such, urinary stone disease seems to be associated with a low antioxidant vitamins’ status. This might be due to their (vitamins’) increased utilisation to fight the oxidative stress created by the injury of renal tubular cells, which might have been induced by the crystals of stone.