DOI: 10.36347/sjams.2020.v08i05.032

Pages: 1326-1334

Background: Neurodegeneration is the progressive loss of structure or function of neurons, including the death of neurons. The major neurodegenerative diseases (ND) are Alzheimer's disease (AD), Parkinson’s disease, Amyotrophic lateral sclerosis (ALS), Huntington's disease, Prion diseases, Multiple sclerosis (MS), Neuronal cell death & Epilepsy. These occur as a result of neurodegenerative processes. Homocysteine may promote Alzheimer’s disease by more than one mechanism, including oxidative stress, neuronal cell damage, tau phosphorylation, enhancement of beta-amyloid aggregation, and hyperactivation of NMDA (N-methyl-D-aspartate) receptor. The diseases are incurable of progressive degeneration and/or death of neuron cells. On the other hand, homocysteine is a non-proteinogenic α-amino acid. Serum homocysteine level is considered as a prognostic marker in neurodegenerative diseases. Objective: The aim of this study was to evaluate the serum homocysteine level as an important prognostic marker in neurodegenerative diseases. Methodology and Materials: This case-control study was conducted at neuromuscular disorder clinic, inpatient and outpatient department of neurology, BSMMU Dhaka, Bangladesh during the period from April-2018 to September-2019. Non-random purposive sampling technique was followed to collect the sample. In total 42 patients of several types of neurodegenerative diseases. Among them Alzheimer’s disease patients were 15(36.5%), Parkinson’s disease 11(24.5%), Amyotrophic lateral sclerosis (ALS) disease were 8(18%), Huntington’s disease were 6(15%) and Prion disease were 2(5%) were finalized as case and 42 people without any neurodegenerative disease were finalized as the control group. At the end of data collection, the mean and standard deviation of serum levels of Homocysteine of both case and control group were calculated and analyzed. Results: The correlation coefficient (r) of ∆FS with Hcy is +.142; which indicates Hcy is positively correlated ...