DOI: 10.21276/sasjm.2019.5.7.2

Pages: 91-99

Background: Because burn patients are accompanied by massive tissue destruction, adequate volume replacement is important. We studied the effects of 6% HES 130/0.4 in a balanced electrolyte solution (Volulyte) compared to 6% HES 130/0.4 in a saline (Voluven) regarding acid-base status and electrolytes in burn surgery. Methods: A total of 121 patients who underwent burn surgery were retrospectively reviewed using a medical record. Fifty-nine patients received Volulyte (Group B) and 62 patients received Voluven (Group S). We compared arterial pH, base excess, and serum chloride level using analysis of multivariate regression and pre- and postoperative changes of the two groups after controlling demographic and operational procedural factors. Each group was subdivided into three groups by the burned surface area as a percentage of total body surface area (TBSA) in order to see whether there are differences between the two groups regarding burn severity. Results: Preoperative arterial pH, base excess, and chloride level had no differences between two groups. Postoperative serum chloride level was significantly lower and arterial pH was significantly higher in group B than in group S. Postoperative base excess showed a significant difference between the two groups. There was a tendency of less increase in serum chloride level in patients with ≥ 50% TBSA in group B. Conclusions: Volulyte showed more beneficial effects on acid-base status and serum chloride level than Voluven in burn patients after surgery. Therefore, Volulyte could minimize the possibility of infusion related hyperchloremic acidosis in patients undergoing burn surgery.