DOI: 10.36347/sajb.2019.v07i05.001

Pages: 220–227

Shigella is one of the most common reason for morbidity and mortality all through the world, causing around 125 million Shigellosis per year and an expected 14,000 deaths, generally among children’s of <5 years of age. Bacillary dysentery, a very common bowl disease is caused by Shigella flexneri. The hypothetical protein of Shigella flexneri (>WP_000373624.1) was taken and analyzed for the determination of its molecular and structural characteristics. Additionally, we attempt to forecast a worthy model of >WP_000373624.1 by utilizing in silico techniques related to protein homology and prediction of active sites to develop effective treatment against Shigella flexneri. Pyre2 software was used for the 3D structural analysis through homology modeling. The functional annotation was also performed by CDD Blast. This in silico hypothetical protein analysis can be additionally exploited in molecular drug strategy for other clinically important pathogens.