DOI: 10.36347/sajb.2019.v07i05.003

Pages: 234–242

The present study was aimed to investigate the changes due to two heavy metals exposure in the activity of the antioxidant enzyme, Catalase (CAT), Reduced glutathione (GSH) and Lipid peroxidation (LPO) in the liver of Danio rerio during 5, 10, 15 and 20 days of exposure period. Discharge of heavy metals into river or other aquatic body can change the environmental factor, species diversity and ecosystem, due to their toxicity and bio-accumulation. These heavy metals enter the aquatic ecosystem as a result of direct input of atmospheric deposition, leaching of minerals and soil erosion due to rain water. This cause the hazardous and weaken the mechanism concerned leading to physiological, biochemical and pathological changes. The lead is non essential elements while cobalt is an essential element for living organisms but their presences in fresh water in higher concentration are toxic to living organisms. Its effect on the oxidative enzymes in the liver is investigated in the present study.