DOI: 10.36347/sajb.2019.v07i12.007

Pages: 495-502

Extended release formulations are better over conventional multidose delivery system, particularly for long- term therapeutic effect and for the treatment of chronic disease. Two-layer tablets may be designed for one layer for immediate release of the drug and the second layer for extended release thus maintaining prolonged blood level The tablets had satisfactory physical properties i.e. hardness, friability etc. The objective of present study was to formulate a bilayered tablet, which produce immediate/ extended release of drug having short biological half-life for longer period of time and to evaluate release profile of drug from this formulation. The bilayered tablet is innovation drug delivery system. This type of dosage form for oral administration in which one layer contains immediate releasing drug and another layer contains immediate releasing drug. The result shows that bilayered oral concomitant E.R. formulation of Metoprolol succinate by matrix tablet using hydrophilic polymers in optimum concentration in one layer and second layer of Ramipril with immediate release. The matrix system is most frequently applied among the innumerable methods used in controlled release of drugs from a pharmaceutical dosage form.