DOI: 10.21276/sasjm.2019.5.7.3

Pages: 100-107

Introduction: MethylTetraHydroFolateReductase (MTHFR) C 677 -T Polymorphism is a widely studied genetic mutation all over world not only because of its association with the prevalence of stroke, but also because of the associated hyperhomocysteinemia and potentially preventive nutritional interventions. Methadology: We conducted a hospital based case control study with 75 confirmed cases of Ischemic (ISC) stroke against 100 matched controls, and employed the PCR-RFLP technique to study MTHFR C677T Polymorphism. Results: Among the controls we found the frequency of MTHFR CC, CT and TT genotypes to be 66 (66%), 29 (29%) and 5(5%) respectively. No statistically significant differences in the allelic and genotypic frequencies between ISC patients and controls were found in this polymorphism (p=0.18; OR=0.61; CI=0.31-1.2). Conclusion: MTHFR C677T Polymorphism was not associated significantly with ischemic stroke. Furthermore its association with the various clinical parameters of ISC cases was not found to be significant