DOI: 10.36347/sjams.2023.v11i12.007

Pages: 2031-2037

Background: Intensivists would benefit from an accurate and easily accessible biomarker for identifying patients with different source of infections who require special attention in critical care units due to their higher risk of death. Objectives: The aim of the study was to determine the rapid detection of early sepsis in intensive care unit: comparison of biomarkers - procalcitonin, serum lactate and C - reactive protein. Methods: Prospective, observational study was carried out in the Department of Critical care unit, Evercare Hospital Dhaka, Dhaka, Bangladesh during January 2021 to June 2021. A total of 60 patients were participated in the study. Statistical analyses of the results were be obtained by using window-based Microsoft Excel and Statistical Packages for Social Sciences (SPSS-24), where required. Results: Patients admitted in Intensive Care Unit of different disciplines, of different adult ages 20-60 years. In this present series it was observed that 36.7% patients were blood culture positive among 60 cases, 21.7% were Urine culture positive among 60 cases, 28.0% were Tracheal Aspirate positive among 25 cases, and finally 25.0% were Wound Swab culture positive among 12 cases. Conclusion: Blood culture positivity was the most common, followed by urine culture positivity, tracheal aspirate positivity, and wound swab positivity. Procalcitonin had the highest sensitivity, accuracy, and positive predictive value for predicting sepsis, followed by C-Reactive protein and serum lactate.