DOI: 10.36347/sjavs.2016.v03i03.007

Pages: 199-204

The Effect of Arsenic trioxide alone and in combination with tannic acid, di-sodium hydrogen phosphate (DSHP), alum and effects of sand-charcoal-iron-filter (SCIF) bed filtrated water along with alum on body weight and liver functions in rabbit were carried out on a total of one month old thirty apparently healthy adult Newzealand white rabbits . The rabbits were randomly divided in to six (6) equal groups (A,B,C,D,E & F,) at the ratio of three males and two females in each group, rats of group A was kept as control without giving any treatment, rabbits of group B received arsenic trioxide@100ppm, group C received arsenic trioxide @ 100ppm plus tannic acid @100ppm, group D received arsenic trioxide @ 100ppm plus di-sodium hydrogen phosphate(DSHP )@100ppm, group E received arsenic trioxide @100ppm plus alum @100ppm orally daily for 60 days in all cases and group F received alum@100ppm in SCIF-bed filtrated water orally daily for 60 days. The result showed that body weight gain of control group (A) per week per rabbit was found to increase but in treated group B (arsenic trioxide@100ppm orally daily) the mean body weight were decreased gradually and significant (P<0.05) decrease in body weight was observed at 40 days of feeding and at day 60 it was highly significant (P<0.01). Rabbits of group C, D and E were apparently normal and mild body weight reductions were observed which was statistically insignificant. No body weight loss was observed in rabbits of group F. A most significantly (P< 0.01) increased SGOT and SGPT values were observed in Group B on day 60 but significant increase (P< 0.05) were observed in day 30. From the study it was concluded that treatment with arsenic trioxide at low doses has adverse effects on body growth and liver functions in experimental animals.