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Scholars Journal of Applied Medical Sciences | Volume-8 | Issue-06
Correlation of EGFR & CK 5/6 Expressions with Histological Grading of Breast Carcinoma
Pawan Trivedi, Vidhi Verma, Anshita Arora, Pallavi Dubey
Published: June 24, 2020 | 153 142
DOI: 10.36347/sjams.2020.v08i06.024
Pages: 1514-1518
Breast cancer comprises a group of very diverse diseases, which can be demonstrated at the molecular, histopathological and clinical levels. Aim of the study were to evaluate Cytokeratin 5/6 (CK 5/6) and Epidermal Growth Factor Receptor (EGFR) expression and correlation with the histological grading of breast carcinoma. EGFR and CK 5/6 are easily available and specific IHC substitute for basal markers. Cytokeratin (CK) 5/6 and EGFR markers have been used in a panel format to identify “basal-like” carcinomas. Methods: The study was performed for the expression of CK 5/6 and EGFR by Immunohistochemistry (IHC) in 48 breast carcinoma patients, underwent for radical mastectomy and were correlated with the MBR histopathological tumor grades for any significance. Result: Among 48 breast carcinoma cases, majority were grade II followed by grade III and grade I. However, on statistical analysis of correlation of EGFR and CK5/6 expressions with tumor grades were found to be significant with P value (= 0.032661) with grade III tumour. The result calculated by SPSS software. Conclusions: Expressions of basal markers like CK 5/6 & EGFR were found to be statistically significantly correlated with the histological grading of breast carcinoma with majority cases having grade III tumor.