DOI: 10.36347/sasjm.2023.v09i12.009

Pages: 1297-1300

Kaposi sarcoma (KS) is an angiogenic neoplasia characterized primarily by purplish to brownish skin lesions. Most often linked to infection by human herpes virus type 8 (HHV8), it affects men more than women and has especially been found in elderly people around the Mediterranean. Classic Kaposi sarcoma is rare and the association with multiple myeloma (or Kahler's disease) remains exceptional with a few cases sporadically described in the literature. We report a new case illustrating this association. This is a 70-year-old patient in whom classic Kaposi disease was recently diagnosed by skin biopsy with positive HHV8 serology. He was subsequently referred to the Department of Nephrology due to the fortuitous discovery of severe kidney failure with a renal biopsy in favour of myeloma light chain cast nephropathy. The hypothesis incriminating an HHV8 variant in the pathogenesis of multiple myeloma is known in the literature but not yet elucidated. It is therefore of great interest that clinicians be sensitized about this association in order to progress in research and improve treatment and prognosis.