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Scholars Journal of Applied Medical Sciences | Volume-8 | Issue-06
Original Research article A Retrospective Study of Coagulation Profile in Patients of Pregnancy Induced Hypertension (PIH)
Dr. Shashikant Mavadiya, Dr. Ashish Jawarkar
Published: June 30, 2020 | 127 82
DOI: 10.36347/sjams.2020.v08i06.041
Pages: 1622-1624
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Abstract
Background: Normal pregnancy is a hypercoagulable state; a physiological safety valve aimed at preventing excessive maternal blood loss at delivery. It is essential to know the range of variations of the coagulation factors during normal pregnancy, if any specific component has to be incriminated as a causative agent for the vascular disorder. Objectives: The main objective of the study is to evaluate Coagulation Profile in Patients of Pregnancy Induced Hypertension. Methodology: This prospective study includes 120 females of uncomplicated pregnancy of age group 16-35 years as a control group and 120 females of same age group with pregnancy induced hypertension (PIH) attending obstetric outdoor patient department (OPD) of our institute from January 2005 to December 2006. Blood samples are collected from all participants for coagulation study that includes Platelet Count (PC), Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT). Results obtained are analyzed statistically to see the significance of difference by calculating p-value. P-value less than 0.05 is considered as a difference of significance. Results: Among total 120 PIH cases, 44 were mild GH, 11 cases were severe GH, 34 cases were mild preeclampsia and 31 cases were in severe preeclampsia group. The mean value of PT and APTT is found to be high in PIH cases as compared to control group. Conclusion: The specific coagulation parameters like Platelet count, PT and, APTT can be safely used as an early indicator for the assessment of severity of PIH cases and can be used to monitor the progression of gestational hypertension to preeclampsia.