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Scholars Academic Journal of Pharmacy | Volume-13 | Issue-01
Calendula officinalis - A Crucial and Promising Antifungal Agent with Cytotoxic Biological Attributes
Hrithik Dey, Mahewish Tarannum, Pankaj Kumar, Vatsala Agarwal, Eliza Parvez, MD Naushad Ali, Sufia Shafieq, Vikas Sharma
Published: Jan. 25, 2024 |
550
165
DOI: 10.36347/sajp.2024.v13i01.004
Pages: 30-36
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Abstract
Globally recognized for its antifungal and anti-inflammatory properties, Calendula officinalis (Marigold) comprises various constituents, including carbohydrates, amino acids, terpenoids, glycosides, lipids, fatty acids, and carotenoids. In in-vitro assessments, it demonstrated effectiveness ranging from 54% to 79% against fungal infections, attributed to the significant presence of sesquiterpene, hydrocarbons, sesquiterpenols, δ-cadinene, α-cadinol, and epi-α-muurolol. Conversely, it also showcases robust cytotoxic activity against colon cancer, leukemia, and melanoma cells in human cancer lines, primarily due to the existence of two triterpene glycosides, calenduloside F 6¢-O-n-butyl ester, and calenduloside G 6¢-O-methyl ester.