DOI: 10.36347/sjams.2020.v08i07.003

Pages: 1651-1655

Objective: In this study our main goal is to evaluate the ascitic fluid fibronectin level to differentiate malignant from nonmalignant ascites. Method: This observational, cross sectional type study conducted in Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka from September 2014 to February 2017. During the study period of total 60 patients (30 patients with malignant ascites and 30 patients with nonmalignant ascites) were enrolled for the study. Results: Mean ascetic fluid fibronectin was found 0.50±0.15µg/ml in malignant ascites group and 0.22±0.07µg/ml in nonmalignant ascites group. Mean ascitic fluid fibronectin was found 0.64±0.11 µg/ml in positive for malignant cell group and 0.45±0.17 µg/ml in negative for malignant cell group. The mean difference was not statistically significant (p>0.05) between two groups. Sensitivity of cut off value of ascitic fluid fibronectin ≥0.22 µg/ml was 82.86%, specificity 96.0%, accuracy 88.33%, positive and negative predictive values were 96.67% and 80.0% respectively. Conclusion: The present study revealed on the usefulness of fibronectin in the differential diagnosis of ascites and these data and findings suggest that fibronectin may have potential value to differentiate malignant from nonmalignant ascites.