DOI: 10.36347/sjams.2020.v08i07.010

Pages: 1689-1695

Introduction: Sodium valproate is proposed for addition to the Model List of Essential Medicines, for use in the management of epilepsy in children. This is an effective in treating many seizure types, like generalized tonic clonic seizure, myoclonic seizure, absence seizure, in other epilepsy syndrome like infantile spasm, Landau-Kleffner syndrome (LKS) etc. Aim of the study: The aim of this study was to observe the side effects caused by sodium valproate in children below 2 years of age. Methodology: This observational cross sectional study was conducted in the Paediatric Neurology patient, department of National Institute of Neurosciences and Hospital (NINS), Sher-e-Bangla Nagar, Dhaka, Bangladesh, during September 2015 to February 2016. Fifty children under 2 years of age with epilepsy were enrolled in this study. Enrollment was done as per inclusion criteria and after informed verbal consent from the mother or the attendant. Detail history was taken about demographic factors which include children’s age, age of onset of seizure, height, weight. Data were collected in a pre-designed questionnaire. The data was processed and analyzed by the application of SPSS version 17. Results: Out of total studied respondents the male patients were 54% and female were 46%. Maximum 46% patients were diagnosed with epilepsy between 6-12 months, Out of total studied patients the maximum 44% started sodium valproate ages between 7-12 months. Among the total studied patients 40% toke 26-30mg/kg/day sodium valproate as their treatment regime. Total 16% had anaemia among the studied patients, whereas for the rest 84% patients no other symptoms were found during their general examination. Among the total studied patients, the most dominating side effect of the patients was vomiting which resulted 1/5th (20%) of the all side effects. The side effects of both hair loss and loss of appetite shows the same result of 10% for each whereas, only 4% and 2% had abdominal pain and ............