DOI: 10.36347/sjmcr.2024.v12i03.037

Pages: 379-384

Background: There are many scientific studies today showing the role of PDT in wound healing. Also, one of the last progressive methods for healing purposes is applying exosomes. Objectives: We investigated the healing process of sever and large-scale injuries and resisting wounds following riboflavin-mediated photodynamic therapy (PDT) that can easily disinfect the wound region in cellular and sub-cellular levels. On the other side, exosomes are one of the most rapid growing methods for regenerative purposes. Materials and Methods: Five subjects with large surface wounds and injuries were treated with PDT (laser irradiation 375 nm and 447 nm, 10 J/cm2, 100 mW) in combination with autologous exosome derived from adipose tissue. Major changes in the wound area have been illustrated. After PDT, 10 billion (in 5ml volume) of adipose derived exosome were applied on a wound trans-dermally. Results: All cases had clinical improvement in the wound area after two weeks without surgery. Conclusion: PDT in combination with exosome therapy can be applied on a large scale and resistant infected wounds as a complementary medicine.