DOI: 10.36347/sjams.2020.v08i08.003

Pages: 1813-1817

Background: Osteoarthritis (OA) is a leading cause of disability and frequent visits to primary care practitioners for those with the condition in comparison to those without. OA affects the knee more often than any other joint of the human body. Platelet-rich plasma (PRP) which is also known as autologous conditioned plasma is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to remove red blood cells. Now it is used in treating OA also. Aim of the study: The aim of this study was to evaluate the role of platelet-rich plasma in osteoarthritis of knee-joint. Materials and methods: This prospective observational study was conducted in the Department of Orthopaedics & Traumatology, TMSS Medical College, Bogura, Bangladesh during the period from January 2018 to December 2018. In total 120 patients more than 40 years of age, diagnosed with grade I and II arthritis were included in this study as the study population. To all the participants three PRP injections were injected in the knees at 4-week interval. Patients were followed up and were assessed for pain and physical activity associated with arthritis using the Western Ontario and McMaster University Arthritis Index (WOMAC) score at the time of induction in the study and at 6 months interval. Results: The mean WOMAC score before the starting of treatment was 82.94 (±5.12) and after 6 months it was reduced to 37.87 (±4.73), which was statistically significant (p= 0.0001). WOMAC score was improved more in the subgroup with patients having symptoms less than 2 years (p=0.0254). On the other hand, in case of subgroups with Kellgren-Lawrence grade 1 or 2 the p value was 0.0730 and there was not any significant difference in the WOMAC score at 6 months among males or females (p=0.1511). Conclusions: The proper sequential use of PRP injection for the treatment of osteoarthritis of knee-joint proved to be effective in our study. The findings of this study may be helpful....................