DOI: 10.36347/sjmcr.2024.v12i04.033

Pages: 524-527

Primary lymphoepithelioma-like carcinoma of the skin is an uncommon condition with limited likelihood of spreading to other parts of the body. Its appearance and characteristics resemble those of lymphoepithelial carcinoma found in the nasopharynx. We report a case of a rare tumor involving a 68-year-old man with a small, pearl-like bump below the ear helix, about 1.2 cm wide. Initially suspected to be basal cell carcinoma or squamous cell carcinoma, the lesion was surgically removed. Examination under the microscope revealed a cancerous growth featuring clustered cells with large nuclei, surrounded by dense infiltration of lymphocytes. Immunohistochemical testing showed the presence of cytokeratin-positive cells (AE1/AE3) and, indicating the tumor's origin from epithelial cells with squamous differentiation. This highlights the importance of considering primary lymphoepithelioma-like carcinoma when encountering skin lesions.