DOI: 10.36347/sjams.2020.v08i08.010

Pages: 1843-1851

Introduction- Larynx is one of the most common sites of head and neck carcinoma. Nasopharyngeal carcinoma is relatively uncommon. Juvenile nasopharyngeal angiofibroma is a very rare disease but gradually increase in the incidence in the current decade as compared to the 1980s suggesting that some evolving host-agent- environmental interaction or probably a novel etiologic agent operating in this part of the world. Materials and method: Total 53 patients from ENT department, having laryngeal or nasopharyngeal masses are included in this prospective study. During operation, part of the tissue is taken in phosphate buffer solution for detection of EBV-LMP-1 by PCR and part of tissue is taken in formalin for histopathology. Result: Out of 35 cases of laryngeal masses, 32 patients (91.4%) are male, 14 patients (40%) are in 6th decade, 22 patients (62.86%) are smoker, 20 patients (57.14%) presented with hoarsness of voice, 8 patients (22.86%) have mass in both vocal cord, 21 patients (60%) have moderately differentiated squamous cell carcinoma, 6 (17.14%) have vocal cord nodule, 2 (5.71%) have fibro-epithelial polyp with dysplasia, 2 (5.71%) have dysplasia, 2 (5,71%) have squamous cell papilloma with koilocytic changes. Remaining 2 patients have cavernous haemangioma and inverted papilloma. Out of 18 cases of nasopharyngeal masses, 14 patients (77.78%) are male, 5 patients (27.78%) are in 2nd decade and 4 patients (22.22%) are in 6th decade, 9 patients (50%) are smoker, 10 patients (55.56%) presented with swelling in cervical region, fever and weight loss, 9 patients (50%) have undifferentiated non-keratinizing nasopharyngeal carcinoma, 6 patients (33.33%) have nasopharyngeal angiofibroma. Remaining 3 patients have keratinizing squamous cell carcinoma and non-Hodgkin lymphoma. But EBV- LMP-1 is not found in any laryngeal or nasopharyngeal cases in this study. Conclusion: Most of the laryngeal masses are diagnosed as moderately differentiated squamous cell carcinoma.....